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1996-02-27
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Document 0059
DOCN M9630059
TI Use of BCG in high prevalence areas for HIV.
DT 9603
AU Felten MK; Leichsenring M; Tuberculosis Unit, University of Heidelberg
Medical School,; Germany.
SO Trop Med Parasitol. 1995 Jun;46(2):69-71. Unique Identifier : AIDSLINE
MED/96131070
AB Recommendations state that, where the risk of tuberculosis is high, BCG
should be administered to infants as early in life as possible, even if
the mother is known to be HIV-infected. BCG should be withheld from
individuals with symptomatic HIV infections. However, continuing reports
from sub-Saharan Africa and elsewhere of BCG complications in
HIV-infected persons call for a re-assessment of current vaccination
policies. For HIV-infected infants any benefit of BCG vaccination may be
marginal because the prognosis is very poor. It is however not possible
to exclude HIV-infected children from BCG vaccination at birth.
HIV-uninfected infants born to HIV-infected mothers are at great risk of
tuberculosis infection, which justifies routine vaccination. BCG rarely
causes serious complications. Theoretically, persons with asymptomatic
HIV infection may be at greater risk of complications from BCG vaccines,
but available data are inconclusive in that respect. To vaccinate
children with BCG at one year of age does not seem feasible and would
increase the risk of tuberculosis especially for uninfected infants of
HIV seropositive mothers. Available data seem to indicate that routine
vaccination of newborns is indeed safe, even in areas with high
prevalence of HIV infection.
DE Africa South of the Sahara/EPIDEMIOLOGY AIDS-Related Opportunistic
Infections/*PREVENTION & CONTROL *BCG Vaccine/ADVERSE EFFECTS Disease
Transmission, Vertical Female Human HIV
Infections/EPIDEMIOLOGY/*PREVENTION & CONTROL/TRANSMISSION *HIV
Seroprevalence Infant Infant, Newborn Pregnancy Pregnancy
Complications, Infectious/VIROLOGY Risk Factors Support, Non-U.S.
Gov't Tuberculosis, Pulmonary/EPIDEMIOLOGY/ETIOLOGY/*PREVENTION &
CONTROL JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).